Best Fertility Tools and Supplements for PCOS

Many women with polycystic ovarian disease (PCOS) often wonder whether they ovulated during a given menstrual cycle. The fertile window is very short and generally lasts five days, typically from four days before egg release to the day of ovulation (included).

However, due to hormone imbalance, which is typical in women with PCOS, this makes it very challenging for these women to determine when they should have intercourse.

This post will describe some tools that can come in handy for women with PCOS. We shall also look at some supplements for PCOS that can help improve fertility in women with irregular cycles.

Fertility Tools for PCOS

Every woman, married or single, should be well acquainted with her body and understand her cycles. She should know what is going on in her body each month and know when her cycles take place.

Even if your cycles are irregular, tools such as fertility monitors and basal thermometers can help give you an idea of what is happening (or happened) in your body.

OvaCue Fertility Monitor

This monitor is ideal for women with PCOS because they do not have to worry about buying expensive test sticks each month. The OvaCue Fertility Monitor comes with reusable sensors that you can use every day.

The Ovacue monitor is very sensitive (approximately 98%) and easy to use. You can view your fertility status on your device and connect it to to automatically sync your data.

This device can help predict up to seven days in advance when you’ll ovulate, so you can start having intercourse during your fertile period.

Additionally, the device stores your data so you can share it with your ob-gyn or fertility specialist, if necessary. 

Lady-Comp Fertility Monitor

This intelligent fertility computer will notify you when it determines days when intercourse would most likely lead to pregnancy.

It has an accuracy rate of approximately 99.3%.

This fertility computer will be monitoring your cycle as it is. One of the advantages of using Lady-Comp in PCOS is that it learns and adjusts to your individual cycle, regardless of your cycle lengths.

This easy-to-use fertility monitor effectively detects your fertile (five days up to ovulation and the day of ovulation) and non-fertile days.

It will display the results using color codes: ‘Green lights’ indicate non-fertile periods, ‘Yellow lights indicate that the monitor has the day under observation, and ‘Red lights’ indicate fertile days.

Generally, Red lights will be observed on a few days before ovulation and for 48 to 72 hours after ovulation has been confirmed. However, if you get a higher frequency of Red lights, this indicates that ovulation was not detected in that cycle.

Lady-Comp measures your oral basal body temperature taken orally, and it uses bio-mathematical forecasting calculations to determine your fertile days. It also analyzes your menstrual cycle data to help you know when you are ovulating.

Supplements for PCOS

Although there is no cure for PCOS, some supplements can dramatically improve your symptoms. Note that it is always advisable that you discuss with your doctor before taking any supplements for PCOS.


This all-natural reproductive support dietary supplement contains several vitamins and antioxidants. It includes myo-inositol, folate, coenzyme Q10, vitamin E, melatonin, grapeseed extract and alpha-lipoic acid.

Melatonin plays an important role in regulating the reproductive cycle. This hormone is found in high levels in your ovarian follicular fluid, where it exerts direct effects on ovarian function. If your body doesn’t produce enough melatonin, this may be worsening your infertility issues.

Myo-inositol is a chemical compound that is naturally-occurring in many plants. Studies have shown that it improves insulin sensitivity and causes your cells to use glucose.

Several studies have shown that women who received a combination of 4 g myoinositol and 400 μg folic acid per day had improved rates of ovulation and regularization of menstrual cycles.


Pregnitude, sold as Inofolic in Europe, contains 200 μ g of folic acid and 2000 mg of myo-inositol. Supplements containing folic acid have been shown to help improve egg quality and ovarian function.

Pregnitude has been shown to improve insulin resistance in women with PCOS and can, therefore, serve as an alternative for women with PCOS who don’t tolerate metformin.

Additionally, women who received Pregnitude experienced a decrease in acne and hirsutism and had a reduction in the frequency of anxiety and mood disorders.

However, for the best results, it is recommended that you also follow a diet and make lifestyle modifications while taking Pregnitude.

Glucorein HOP

This dietary supplement supports ovulation, regulates the menstrual cycle, and improves egg quality. It contains chlorogenic acid, N-acetylcysteine, myo-inositol, and pomegranate extract.

Several studies have shown that chlorogenic acid inhibits glucose-6-phosphatase, an enzyme that promotes the formation of glucose in the liver.

Therefore, scientists believe the association between coffee consumption and a decreased risk of insulin resistance and diabetes mellitus may partly be due to the presence of chlorogenic acid in coffee.

Other investigators found that chlorogenic acid may slow fat absorption from food and activate fat metabolism.

Although women taking Glucorein HOP have reported a decrease in acne and sugar/carbohydrate cravings as well as improvements in their menstrual cycles, there have no reports that this supplement can help with hair loss.

You should be aware that there are no studies showing the efficacy of Glucorein HOP. Thus, if you’re planning to use this supplement, you should talk to your doctor for the best advice.

Further Reading

  1. Regidor PA, Schindler AE, Lesoine B, Druckman R. Management of women with PCOS using myo-inositol and folic acid. New clinical data and review of the literature. Horm Mol Biol Clin Investig. 2018 Mar 2. pii: /j/hmbci.ahead-of-print/hmbci-2017-0067/hmbci-2017-0067.xml. doi: 10.1515/hmbci-2017-0067.
  2. Regidor PA, Schindler AE. Myoinositol as a Safe and Alternative Approach in the Treatment of Infertile PCOS Women: A German Observational Study. Int J Endocrinol. 2016;2016:9537632. doi: 10.1155/2016/9537632.
  3. Tamura H, Takasaki A, Taketani T, Tanabe M, Kizuka F, Lee L, Tamura I, Maekawa R, Aasada H, Yamagata Y, Sugino N. The role of melatonin as an antioxidant in the follicle. J Ovarian Res. 2012 Jan 26;5:5. doi: 10.1186/1757-2215-5-5.
  4. Salehpour S, Akbari Sene A, Saharkhiz N, Sohrabi MR, Moghimian F. N-acetylcysteine as an adjuvant to clompiphene citrate for successful induction of ovulation in infertile patients with Polycystic ovary syndrome. J Obstet Gynaecol Res. 2012 Sep;38(9):1182-6. doi: 10.1111/j.1447-0756.2012.01844.x.
  5. Batıoğlu AS, Sahin U, Gürlek B, Oztürk N, Unsal E. The efficacy of melatonin administration on oocyte quality. Gynecol Endocrinol. 2012 Feb;28(2):91-3. doi: 10.3109/09513590.2011.589925.
  6. Eryilmaz OG, Devran A, Sarikaya E, Aksakal FN, Mollamahmutoğlu L, Cicek N. Melatonin improves the oocyte and the embryo in IVF patients with sleep disturbances, but does not improve the sleeping problems. J Assist Reprod Genet. 2011 Sep;28(9):815-20. doi: 10.1007/s10815-011-9604-y.
  7. Rizzo P, Raffone E, Benedetto V. Effect of the treatment with myo-inositol plus folic acid plus melatonin in comparison with a treatment with myo-inositol plus folic acid on oocyte quality and pregnancy outcome in IVF cycles. A prospective, clinical trial. Eur Rev Med Pharmacol Sci. 2010 Jun;14(6):555-61.
  8. Olthof MR, van Dijk AE, Deacon CF, Heine RJ, van Dam RM. Acute effects of decaffeinated coffee and the major coffee components chlorogenic acid and trigonelline on incretin hormones. Nutr Metab (Lond). 2011 Feb 7;8:10. doi: 10.1186/1743-7075-8-10.
  9. Henry-Vitrac C, Ibarra A, Roller M, Mérillon JM, Vitrac X. Contribution of chlorogenic acids to the inhibition of human hepatic glucose-6-phosphatase activity in vitro by Svetol, a standardized decaffeinated green coffee extract. J Agric Food Chem. 2010 Apr 14;58(7):4141-4. doi: 10.1021/jf9044827.
  10. van Dijk AE, Olthof MR, Meeuse JC, Seebus E, Heine RJ, van Dam RM. Acute effects of decaffeinated coffee and the major coffee components chlorogenic acid and trigonelline on glucose tolerance. Diabetes Care. 2009 Jun;32(6):1023-5. doi: 10.2337/dc09-0207.

I’m Princila, founder of Check Ovulation and a proud mom of two. I’m an alumna of James Lind Institute. After working in clinical jobs, my passion for writing took its toll, and I ended up switching careers to work in the medical publishing industry. I also have a passion for healthy food, which prompted me to take several online courses in nutrition and health offered by Wageningen University. (I still haven’t completed the courses thanks to my busy mommy schedule!). When I’m not writing/editing scientific and medical manuscripts or taking care of my family, I use my free time to research, learn, and write about healthy living. I have also authored a few books in the self-help niche using the pen names Princila Murrell or PN Murray. Protection Status